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Innovative approaches should leverage and combine advances in both experimental and computational methods, including machine learning and artificial intelligence, to rapidly identify formulation compositions for viscosity reduction, and subsequently facilitate the development of patient-centric biotherapeutics

Although improvements in the transparency, harmonization, and adherence to best practices for clinical trial sites would benefit the efficiency and quality of clinical trials, moving to an accreditation system may not be realistic at this time

Nanoparticles size, size distribution, zeta potential Dynamic light scattering technique (DLS) coupled with a computerized inspection system (Malvern Zetasizer, Nano-ZS, Malvern, UK) and DTS nano software was used to determine size, polydispersity index (PDI) and zeta potential of develop NPs

Standard Contraindications Apply All GLP-1 contraindications remain in effect: personal or family history of medullary thyroid carcinoma, MEN2 syndrome, history of pancreatitis, pregnancy, and known hypersensitivity