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[100] using circulating endothelial progenitors named endothelial colony-forming cells, accelerated endothelial senescence in smokers and patients with COPD was shown compared with healthy controls

Front Pharmacol 9:128

It is essential for safety and tolerability

In addition, JMJD6 promotes the maintenance of mHSC self-renewal by suppressing OXPHOS and other detrimental mechanisms, such as p53 stabilization 108