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Interfaces 14 , 464473 (2022)

SIBYLS is funded through the DOE Office of Biological and Environmental Research Integrated Diffraction Analysis Technologies program

Although almost all tissues in the body have some ability to metabolize chemicals, smooth endoplasmic reticulum in the liver is the principal "metabolic clearing house" for both endogenous chemicals (e.g., cholesterol, steroid hormones, fatty acids, proteins) and exogenous substances (e.g., drugs, alcohol)