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In vitro drug release profiles demonstrated a steady release of the drugs over 2 weeks, and in vivo behavioral and molecular tests were conducted to assess efficacy and biological responses

Oxidative stress triggers apoptosis in vascular smooth muscle cells, reshapes the extracellular matrix (ECM), and governs ECM degradation and remodeling, subsequently impacting aortic compliance

Except for the limited agents under clinical assessment, the preclinical research of other agents targeting this signal axis is continuously attracting attention