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The second component tracked the natural history of NAFLD progression in adults, encompassing 14 distinct health states including no steatosis, simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, decompensated cirrhosis, hepatocellular carcinoma (HCC), LT, and liver-related or other causes of death

Therefore, it is exciting that this study finds that GlyNAC supplementation appears to improve the components of four aging hallmarks (i.e., improvements in mitochondrial dysfunction, inflammation, insulin resistance and genomic damage) and warrants further study in a randomized clinical trial

Diabetes Care 2004

While short-term LC supplementation has demonstrated positive effects, including increased endurance, improved hepatic fat metabolism, and myocardial stability, evidence indicates that the prolonged supplementation may pose risks, particularly for individuals with pre-existing cardiovascular or renal conditions