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In the present study, it is presumed that autophagy is induced by increased oxidative stress in EAAC1 and GLAST KO mice, and NAC suppressed autophagy and promoted RGC protection by reducing oxidative stress

In particular, the constant high urinary background levels of NAcLys-BDA in the range of NAcLys-[ 13 C 4 ]-BDA concentrations observed in response to the highest dose of [ 13 C 4 ]-furan (1 mg/kg bw) and estimated to correspond to a furan intake of 1.6 and 2.1 mg/kg bw in male and female rats, respectively, provide clear evidence for a significant but yet unexplored source of furan or its metabolites

The samples were incubated at room temperature (25 C) on a shaker (100 rpm) for 24 h

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