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They add that as immunotherapies are being more commonly utilized as first- and second-line treatments, immunotoxicity and autoimmunity are emerging as the Achilles heel of immunotherapy. In their Cancer Immunology Research paper, Bluestone and colleagues briefly discuss immunotherapeutic strategies that can potentially prevent irAEs, such as targeting intratumoral T cells directly, using bispecific antibodies to enhance localized targeting of tumor, and using engineered cell therapies to fine-tune immune cell responses

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Given that mitochondrial one-carbon metabolism is very important for cancer progression, the entry of serine into the mitochondria is a critical step in the generation of one-carbon units