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224 The lysine deacylase activity of SIRT4 is involved in the control of leucine metabolism and insulin secretion through regulating the acylation status of enzymes in these pathways

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The MCC is one of three approaches that Mtb can use to metabolise the potentially toxic propionyl-CoA that is derived from the catabolism of host-derived sterols, odd-chain fatty acids and branched-chain amino acids, substrates that are present and utilised in vivo (Lee et al, 2013)