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Faded hyperpigmentation: Documented in Finkley 2005 as reduced mottled pigmentation, supported by GHK-Cus MMP-modulating activity

MOTS-c, as a small molecular active peptide, has been reported to have potential applications in aging, insulin resistance, cardiovascular disease and inflammation ( Figure 1 )

Moreover, another study documented that 400 mg/d riboflavin supplementation during 3 months had the same favorable effects as 500 mg/day sodium valproate on patients with migraine (36)