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Double-strand breaks may also occur as repair intermediates during the resolution of oxidatively induced clustered DNA lesions (Sage and Harrison 2011), consisting of closely located lesions, typically within 20 base pairs, which include abasic (AP) sites, oxypyrimidines, oxypurines, and single-strand breaks (Kryston et al

Once we figure those things out, the next step is understanding where these molecules need to go in the system

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