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The British National Formulary (BNF), for example, differentiates the prescription of hydroxocobalamin according to presenting symptoms, eg, For neurological involvement, it is advised to administer hydroxocobalamin by intramuscular injection, initially 1 mg once daily on alternate days until no further improvement, then 1 mg every 2 months. In the Netherlands, pharmacotherapeutic guidelines 51 recommend (for the same neurological symptoms or abnormalities) administration of 1000 mcg once or twice weekly for up to two years

And with that, the companys ambitions of getting it FDA-approved as a prescription medication effectively ended

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B12 deficiency can also lead to weakness and fatiguetwo culprits that often keep people from sticking to their diet and exercise plans