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The findings will allow the design of a larger, randomized controlled trial to rigorously assess the clinical benefit of this therapeutic approach while helping to decide which patient group will more benefit

Noise exposure induced a chronic tinnitus percept as measured by startle reflex inhibition In the use of the PPI paradigm as a behavioral assay, we collected data from 34 companion controls to construct a 95% confidence interval (CI) for the mean tinnitus index score, which served as the normative reference for estimating tinnitus

These cases often involve an interplay between neuroautoimmunity and immune hypersensitivity, with mast cells amplifying the inflammatory response to microbial triggers