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For instance, NRF2 levels in pulmonary epithelial and colorectal cancer cells and the rat retina remain unchanged or are reduced during hypoxia 4345 , suggesting that other transcription factors activated by hypoxia, such as nuclear factor kappa B (NF-B) and forkhead box O3 (FoxO), primarily lead to increased antioxidant protein expression levels 10

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These rate constants were used to determine the remaining kinetic parameters k +3 , k 3 , and k 5 by fitting the experimental data of the SetCys-mediated ligation (circles and triangles in Fig