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The most common warning signs are: Fatigue Dizziness Weakness Nausea Vomiting Diarrhea Pale or yellowish skin Mood changes (depressed or irritable) Sore mouth and/or a swollen tongue Numbness and tingling in the extremities Difficulty walking or speaking like normal Memory impairment and/or forgetfulness Changes in cognition Diagnosis and treatment Because symptoms are not always present, providers usually choose a variety of blood tests to check for a B12 deficiency

Furthermore, caspase 3 signaling and TUNEL assays were conducted to assess neural apoptosis

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The chemical composition and crystal structure of NPs are also critical to determine their toxicity