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Your body produces it on its own, but production declines significantly with age, from roughly 200 ng/mL at age 20 to around 80 ng/mL by age 60

Research Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models Mu X, Qu L, Yin L, Wang L, Liu X, Liu D (2024, October) This study developed a novel fusion peptide, DSIP-CBBBP, combining delta sleep-inducing peptide (DSIP) with a blood-brain barrier crossing peptide, produced via Pichia pastoris

The main risks stem from its unapproved status and potential for improper compounding

Topical Versus Injectable: Which Causes More Issues