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Ce- 76 3 The Micronutrients Signs and Symptoms of Recommended Daily Intakes Deficiency1,3,4 Recommended daily intakes for copper (mg) Anemia resembling iron-deficiency anemia but not completely responding to iron, accompa- Prevention of deficiency nied by leukopenia and neutropenia UK RNI (1991) USA ESADDI (1989) Abnormal skeletal growth, osteoporosis Changes and loss of hair and skin pigmentation Adult men 1.2 1.53 and vitiligo Adult 1.2 1.53 Weakness and fatigue women Increased vulnerability to oxidative damage (low Therapeutic dose range activity of ceruloplasmin and Cu/Zn SOD) Werbach (1990/99) Hypercholesterolemia, hypertriglyceridemia, Adult men 210 and glucose intolerance Adult 210 Possible increase in fragility of blood vessel walls women and increased risk of aneurysm Preferred Form and Dosage Possible weakening of immune responses and Schedule impaired activation of T cells Good Dietary Sources Although copper sulfate Take between meals, is the most common preferably with the dose Food Serving size mg supplemental form, divided throughout the Liver (calf) 100 g 3.55.5 organically bound forms day 310 Certain ports and 50 ml of copper (orotate, 2.5 sherry 0.70.8 chelates) may be more Oysters 100 g 0.7 bioavailable 0.5 Lentils, chick peas, 100 g 0.5 kidney beans 0.3 0.3 Sunflower seeds 25 g 0.2 Use in Prevention and Therapy Hazelnuts, walnuts, 50 g Anemia