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In brief, lipidomics for each sample were performed by the Vanquish UPLC systems coupled to a Q Exactive HF (QE-HF) mass spectrometer equipped with HESI (Thermo Fisher Scientific, Waltham, MA)

Comparing them is more useful for understanding the evidence hierarchy in drug development than for choosing between two equivalent options

The clinical data supports this as a rational escalation strategy, though it requires access to investigational cagrilintide

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