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One specific autoimmune disease is type 1 diabetes, characterized by the destruction of pancreatic cells mediated by T cells

Grading of the evidence The certainty of the evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation approach developed for network meta-analyses (Reference Brignardello-Petersen, Bonner and Alexander20)

Comparison of DNA fragmentation and protamine deficiency before and after NAC treatment The mean percentage of DNA fragmentation assessed by TUNEL was 19.34% 0.47 at baseline and significantly decreased after treatment with NAC (15.14% 0.46