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The pathophysiology of DN is multifaceted, encompassing genetic susceptibility, perturbations in glucose metabolism, alterations in renal hemodynamics and the involvement of inflammatory mediators (2)

The elucidation of different mechanisms of disease progression facilitates the development of targeted therapies, while the intrinsic linkages in disease mechanisms are equally noteworthy, as their interactions pose serious challenges for clinical treatment

lumbricoides and serum TNF-, IL-1, IL-10, and IL-12 values, results showed that NO is significantly explained by IL-12 ( R 2 = 0.176

The development of radiosensitizing drugs has therefore found application in the treatment of tumors by radiotherapy