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Running spike-and-recovery experiments during method validation ensures accurate quantification in the intended biological context

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Consistent oral supplementation can reduce the appearance of dark spots over time

This prompted a more detailed sub-analysis of ocular endpoints [37], which showed a significant reduction of the requirement for laser treatment for macular edema (HR 0.69, 95% CI 0.540.87) and of PDR (HR 0.70, 95% CI 0.520.87) in the fenofibrate group relative to placebo