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5-Rs isoforms (types 1, 2 and 3) are widely distributed in many tissues including the central nervous system, and inhibition of these enzymes results in blockade of synthesis of several key hormones and neuro-active steroids ( Figure ) leading to a host of adverse effects, including loss of or reduced libido, erectile dysfunction, orgasmic dysfunction, increased high Gleason grade prostate cancer (PCa), observed heart failure and cardiovascular events in clinical trials, and depression

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doi: 10.2340/00015555-3384 8 EmdinCAKheraAVKathiresanS