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Abbreviations 5-FU: 5-Fluorouracil AD: Alzheimer's disease ADDLs: Amyloid-beta-derived diffusible ligands ASOs: Antisense oligonucleotides AuNPs: Gold nanoparticles AuNPsQ: Quantum-sized AuNPs AuNRs: Gold nanorods AuNSs: Gold nanospheres BCA: Bio-barcoding assay cAuNPs: Citrate-capped AuNPs COVID-19: Corona virus disease 2019 CSF: Cerebrospinal fluid CT: Computed tomography CTAB: Cetyltrimethylammonium bromide DABCYL: 4-((4-(Dimethyl-amino)-phenyl)-azo)benzoic acid DAPT: 4,6-Diamino-2-pyrimidinethiol Dox: Doxorubicin EDC: 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide EPR: Enhanced permeability and retention FA: Folate FDA: Food and Drug Administration FITC: Fluorescein isothiocyanate FRET: Fluorescence resonance energy transfer HAuNSs: Hollow AuNSs HF: High-fat HU 1 : Hounsfield unit LFAs: Lateral flow assays LSPR: Localized surface plasmon resonance MDR: Multidrug resistant MGF: Mangiferin MPA: Mercaptopropionic acid MWPLP: Microwave-induced plasma-in-liquid process NCL: Nucleolin NIR: Near-infrared NSMs: Nanostructured materials P

Nitric oxide (NO) pathway involvement, consistent with earlier research showing BPC 157's regulatory effects on vascular tone and tissue healing

Thus, the enhanced GLUT1 expression induced by metformin in our model probably complements its well-established antitumor actions