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As described in the CY 1998 PFS final rule (62 FR 59048), we consulted with a number of appropriate organizations such as the American Cancer Society, American College of Physicians, American Gastroenterological Association and USPSTF, and the decision to cover the barium enema procedure was based on the prevailing clinical guidelines and recommendations at the time

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[10] [12] High-dose ascorbic acid may diminish the therapeutic effects of certain chemotherapeutic agents, such as bortezomib, due to its antioxidant properties