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Posttranslational modification of Wnts mainly includes lipid modification and glycosylation, and lipid modification is performed by PORCN

In free cysteine, the pK a value of the thiol group is 8.45, which predicts that only a small proportion of cysteines are deprotonated under physiological pH conditions (Table 1) [22]

Might has some anti-oxidant effect A non-living ingredient made by fermentation with the bacteria Lactobacillus

As male mice more robustly develop symptoms of metabolic syndrome than female, only male Ctrl and KO mice were challenged with a 60% high fat diet (D12492, HFD, Research Diets, New Brunswick, USA) for 12 weeks, starting at the age of 5 weeks, before p53 ablation was facilitated by treating the mice with Tamoxifen (100 mg/kg via oral gavage for 5 consecutive days (Molekula group, Munich, Germany) followed by a 1 week wash out period