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270 Moreover, H 2 O 2 was also shown to mediate NF-kB activation in an IKK-dependent way by regulating the PI3K/PTEN/AKT signaling cascade

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However, its inhibition reduces tumor invasion, GSCs self-renewal, and progression, reinforcing its therapeutic potential

Seventy-seven young and healthy volunteers assigned male at birth, some living in urban areas and some living in rural areas, were recruited in the trial