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Our recent SNO-proteome analysis of the cortices of Shank3 InsG3680 (+/+) mutant mice showed that several mitochondrial processes, including the ATP metabolic process, transmembrane electron transport, and the cellular response to oxidative stress, were SNO-enriched [64]

doi: 10.3109/08977190109029114 14 HillJJDaviesMVPearsonAAWangJHHewickRMWolfmanNMet al

Accordingly, here we demonstrated a selective metabolic rewiring affecting GLUT1-dependent glucose metabolism and driving mitochondrial dysfunction in CD4 + T cells in pre-symptomatic AD individuals

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