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Ionic mechanisms of cell death induction/protection involving TRPM2 and TRPM7 Since cell death induction is tightly coupled to dysfunction of cell volume regulation, in which TRPM2 and TRPM7, as already described, play important roles, the ionic mechanisms of cell death induction may, at least in part, involve TRPM2 and TRPM7 channel activities in relation to altered mechanisms of the cell volume regulation

Others notice tingling or numbness in their hands and feet as nerve function becomes affected

Therefore, a person with PCD may lose nearly 95% of their kidney-filtered carnitine in the urine

10.1016/j.tcb.2010.08.015 2