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A recent study demonstrated that the LGR4/Wnt/-catenin pathway activates the transcription of SLC7A11, a gene that resists ferroptosis

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An intermediate effect was observed for the mutant Y110H, which had an approximately three to four times lower catalytic efficiency and reciprocal Dalziel coefficient for GSSCys, but an almost unchanged catalytic efficiency and reciprocal Dalziel coefficient for GSH (Fig