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These results indicated that CHAC1 mRNA degradation by GDIL/XRN2 most likely occurred in the cytoplasm

Wrobel, L., Hill, S

From that standpoint, its probably more the variation in whats happening at the microbiome level as far as exposure to these compounds. Thats why the TMAO synthesis pathway has become one of the first gut microbiota targets for pharmaceutical interventions to prevent CVD,12 even though that pathway is quite complex