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Based on the position of selenocysteine within the polypeptide, selenoproteins can be categorized into two types: the first type, where selenocysteine is located at the N-terminus of the functional group, includes examples such as GPX, selenoprotein P, and selenoprotein W

To increase aqueous solubility of the compounds to facilitate structural studies, the cycloheptyl substituent in TGR uncompetitive inhibitor 8 was replaced with a sugar moiety, resulting in compound 9 , a noncompetitive inhibitor and thus capable of binding the enzyme in absence of NADPH

5.2.4 Novel pharmacotherapies and combination treatment As a multifactorial degenerative disease, OA often responds poorly to single-target therapies (9)