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Spirometry and lung volumes are normal or minimally impaired (opposing effect between the hyperinflation due to the emphysema and the loss in volume due to the fibrosis), but there is a marked and disproportionate decrease in the DLco and significant exercise-induced hypoxemia (probably due to the additive effect of the emphysema, fibrosis and pulmonary vascular disease)

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The half-life of peroxynitrite is short (~1020 ms), but sufficient to cross biological membranes, diffuse one to two cell diameters (312), and allow significant interactions with most critical biomolecules (1041)

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