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The following source settings were used for both scan modes: source voltage 3500 V, resolution 70,000, AGC target 110 6 , mass scan range 60600 m/z, sheath gas 40, auxiliary gas 10, sweep gas 1.5, probe temperature 300 C, capillary temperature 250 C and S-lens RF level 50

As the most widely studied member of the SIRT family, SIRT1 regulates cell biology and metabolism by deacetylating histones or a variety of other cytoplasmic substrates and by inhibiting pro-inflammatory kinases or regulating transcription factors, such as nuclear factor B P65 (NF-B P65) and P38 mitogen-activated protein kinase (P38 MAPK) [14,15,16]

The physiology of melanin deposition in health and disease

Biochemistry (Moscow) 71 (4), 361369