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Therefore, aside from the DNA damage resulting from the promotion of OS due to tobacco, smoking initiates pathways influenced by ROS, connecting to RAS/MAPK, NF-B, and AP-1, contributing to inflammation, programmed cell death, proliferation, and cell specialization

While most adverse effects observed have been manageable, certain patient profiles present a higher risk for complications and should be screened carefully before treatment initiation

Lai et al., 2022), while highly prevalent vitamin D deficiency, impacting bone and potentially lung health, faces repletion challenges despite supplementation efforts (Lai et al., 2022

Pro: Side effects tend to be relatively minimal, because relatively little of the ingredient is being absorbed directly