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Site burden compounds this: as trials expand globally, particularly into Asia-Pacific and other emerging markets, sites increasingly switch between different sponsor-specific systems and processes, which industry commentary describes as a central operational risk in 2026 rather than a solved problem

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Cell 68:799808 Brook JD, McCurrach ME, Harley HG, Buckler AJ, Church D, Aburatani H, Hunter K, Stanton VP, Thirion JP, Hudson T, et al (1992) Erratum: molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3 end of a transcript encoding a protein kinase family member