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doi: 10.1002/brb3.208 128 Sharafati-ChaleshtoriRShirzadHRafieian-KopaeiMSoltaniA

Preclinical studies in COPD models have suggested that mTOR inhibition may reduce airway inflammation, but safety and long-term efficacy remain to be established [141, 142]

Through the lens of genomics and molecular biology there is a great complexity inherent to cellular processes and their interactions, not to mention the pitfalls in variant filtering and classification, including potential errors in alignment, annotation, and variant calling, as well as the challenges of pathogenicity classification under ACMG/AMP guidelines (Richards et al., 2015)