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There is increasing recognition that imbalances in the gut microbial community, referred to as dysbiosis, are associated with a range of neurological disorders

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TSPO, an outer-mitochondrial-membrane protein widely overexpressed in GBM, enhances resistance to chemotherapy and radiotherapy by restraining the caspase-9/Apaf-1-dependent mitochondrial apoptosis pathway [41]

It is therefore important to keep in mind the clinical scenario that is being mimicked, i.e., overdose causing injury and recovery versus a severe overdose with injury, limited recovery, and development of acute liver failure