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Similarly, the reduction in NCOA4 expression, a gene involved in the autophagic degradation of ferritin, known as ferritinophagy [36], further supports melatonins role in modulating iron metabolism to mitigate ferroptosis risk

Therapeutic or experimental strategies targeting aging organize around three main axes: senolytics (selective elimination of senescent cells), senomorphics (SASP modulation without killing cells), and geroprotectors (reinforcement of anti-aging mechanisms like autophagy, mitophagy, telomerase activity)

10.1016/j.bbamcr.2022.119417 Biochim

As mentioned above, there are more than 100 Akt substrates mainly including GLUT4, FOXO1, GSK3, mTORC1, SREBP-1c, TSC1/2, PRAS40, ABHD15, PDE3B