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Local demographic trends in Tenkasi a growing working population, greater health insurance penetration, and rising awareness of chronic-disease management all point toward sustained medicine consumption

As discussed elsewhere, the role of IFN-I in tumor biology and immune responses is, per se, dichotomous, promoting cytotoxicity of NK cells and CD8 + T cells in some circumstances but also the suppressive function of Tregs in others [177,178,179]