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Drug Targets 13 , 984993 (2012)

Several studies employing single-cell RNA sequencing, mass cytometry, and fluorescence cytometry revealed phenotypic alterations in microglia across various models, although spatial information was limitedly obtained and the pathological mechanisms remained unclear at that time

By depleting GSH, CHAC1 enhances cellular oxidative stress, promoting apoptosis, ferroptosis, and necroptosis

In neuroinflammation, SFRP1 upregulates hypoxia-inducible factor (HIF)-dependent inflammatory pathways, promoting microglial activation (Rueda-Carrasco et al., 2021)