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Polar amino acids in the ligand-binding pocket are also important in other peptide hormone GPCRs, such as R327 6.54 in NTSR1 (PDB ID: 4GRV) 21 , R343 6.55 and R357 7.24 in ET B (PDB ID: 5GLH) 24 , and K215 5.42 , D279 6.58 , and D297 7.32 in AT 2 R (PDB ID: 5XJM) 33

R., Volek, J

In a 3D culture format using human biopsy-derived ileal organoids and colonoids, differentiated organoids showed PXR-mediated induction of CYP3A4 expression, a response that is largely absent in parental Caco-2 cells 58

compositions as described herein may be reconstituted in, or may comprise, a liquid carrier (for example, water or juice), allowing for straightforward oral administration