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Mast cells are very proficient producers of proteases and mast cell activation has been proposed as underlying pathogenetic mechanisms in different gastrointestinal disorders, including IBS (217, 218)

Patients using them seem to have an edge but they also fit into the category of patients who were already likely to be more successful in their rehab secondary to other internal/external factors

Even the lowest treatments of NiO-NP (10 mg L 1 ) increased ascorbic acid (2.9-folds) and cysteine contents (1.6-folds)