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Fernandes et al

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

### Discard the Vial If: - It has been more than 30 days since reconstitution - You see cloudiness, particles, or color changes - The vial was left at room temperature for more than a few hours - You suspect contamination (e.g., the stopper was touched without cleaning) When in doubt, discard and start fresh

Transformation photos shared online rarely include controlled conditions, verified dosing, or isolation of AOD-9604's contribution from diet and exercise changes