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Clinically, TK2 -related MDS patients share common symptoms, including progressive myopathy, skeletal muscle involvement (e.g., facial and axial neck flexor weakness), respiratory system involvement, and chronic progressive external ophthalmoplegia (CPEO) (98)

Laboratory investigations demonstrated liver dysfunction, including elevated alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels

Construction of a nomogram A nomogram was created via pN_stage and pM_stage packages after the identification of potential predictors that would predict OS independently through unifactorial and multifactorial COX regression

Combining microneedling with copper peptide application may enhance delivery to deeper skin layers where wrinkle-forming structural changes occur