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b) Detoxification, due to the direct inactivation of 4-HNE with GSH and ascorbate or to the interaction with billions of cells endowed with detoxifying enzymes [42] c) Excretion, into bile and urine after hepatic detoxification [67] and renal excretion [60], and d) Cell internalization , this is a crucial and interesting point because the consequent biological effects can be either negative or positive