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Description

The molecular basis of the enzymatic regulation remained unknown until 2018

13 , e0007672 (2019)

Apart from pangamic acid that occurs naturally, di-isopropyl-ammonium dichloroacetate (DIPA), a synthetic product that does not exist in biological material, is available on the market with claims to have comparable biological properties (201)

A series of recent publications has demonstrated that, in proliferating cells, the pentose phosphate pathway and the previously underestimated THF metabolism have nearly comparable contributions to the regeneration of NADPH from NADP + 54,55,56,57 (Fig