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29 31 Under hypoxia, mitochondrial respiration generates increased ROS, reasoning the diversion of pyruvate away from the TCA cycle, but perhaps another crucial advantage of metabolizing pyruvate through the lactate axis instead is the inherent need for the regeneration of co-factor nicotinamide adenine dinucleotide (NAD) + in order to sustain a continued high glycolytic flux

Muthusamy S, Udhayabaskar S, Udayakumar GP, Kirthikaa GB, Sivarajasekar N (2020) Properties and applications of natural pigments produced from different biological sourcesa concise review