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Higher intestinal permeability induces the translocation of gut bacteria and microbial components that initiate inflammation and oxidative stress in the enteric nervous system, resulting in enteric -synucleinopathy in PD (Bjarnason et al., Inflammation of the gut and neuroinflammation of the brain The maturation and function of microglia are affected by the altered cell proportions, while immature phenotypes are based on the circulating levels of pro-inflammatory and anti-inflammatory cytokines contributing to host homeostasis (Erny et al., via TLRs activation (Lucas and Maes, 2013)

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Key nutrients such as calcium, phosphorus, copper, zinc, and manganese are supplied in balanced ratios to promote proper bone and connective tissue development in the foal, while selenium and vitamin E contribute to immune function and colostrum quality

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