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121,122 Multiple lines of evidences have revealed that IDH1 is overexpressed in numerous cancers and is closely correlated with poor prognoses of patients with non-small cell lung carcinoma (NSCLC), 123 PDAC, 124 or one of several hematological malignancies

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Similarly, pathway inhibition improves hepatocyte apoptosis in acute liver injury 50

Mechanism of oxidative damage Reactive oxygen species, specifically the hydroxyl radical, respond with lipid layers and produces receptive aldehydes, including malondialdehyde and 4-hydroxy-2-nonenal (HNE), in three phage responses