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Erastin, one of the earliest discovered ferroptosis inducers, inhibits system Xc - (SLC7A11/SLC3A2), thereby impairing GSH synthesis, leading to ROS accumulation and inducing GBM cell death ( 2+ levels, increased GSH levels, and suppressed expressions of ferroptosis-related proteins such as GPX4, NRF2, and SLC7A11 ( RAS-selective lethal 3 (RSL3) is a known ferroptosis inducer

(More information) Other Articles Riboflavin is a water-soluble B vitamin, also known as vitamin B 2

Apoptosis of neutrophils

After 24 h of intranasal administration of a proinflammatory dose of LPS (100 ng per mouse), robust neutrophil infiltration was observed in the lungs compared to the PBS group, and comparable numbers of neutrophils were detected in both bronchoalveolar lavage fluid (BALF) and lung homogenates of WT and XKR8 KO mice (Extended Data Fig