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Millicen, O., Bigson, K., & Akwaah, V

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[32] This is to say, then, that the business of enhancing cognition in otherwise healthy subjects is rife with oft-unfulfilled promises and that claims of nootropic effect, especially those derived from findings in animal models of disease states or compromised cognition, should be approached with healthy skepticism

Giordanetto and Kihlberg, 2014) that includes improved membrane permeability compared to acyclic matched pairs and oral bioavailability but also often improved affinity for the target, improved selectivity and reduced metabolism (Hess et al., 2008